Developing a successful biotherapeutic starts with choosing the right cell line. FyoniBio’s CHOnamite® platform offers a flexible suite of CHO production cell lines, including CHO-K1, CHO-GS-KO, and CHO-DG44, designed to deliver high productivity, stability, and optimized product quality for complex proteins.
Different CHO cell lines can significantly influence critical quality attributes such as glycosylation, productivity, and post-translational modifications. Our CHOnamite® platform allows you to select the optimal system for each project —tailored to your molecule’s characteristics, regulatory requirements, and commercial goals.
This flexibility is particularly advantageous in biosimilar development, where selecting the right host system can improve your ability to match the originator’s quality attributes and support regulatory approval.
Our platform
Monoclonal Antibodies
Bispecific Antibodies
Biosimilars
Difficult Proteins
By leveraging CHOnamite®, we initiate projects on a broad scale to maximize the likelihood of identifying the highest-expressing clones. Our pool generation approach integrates CHO-K1, CHO-GS-KO, and CHO-DG44 cell lines, followed by comprehensive analytical characterization, including:
• Glycan profiling
• Aggregate quantification
• Charged variant analysis
• Potency assessment
This thorough evaluation guides the selection of the most promising cell pool for state-of-the-art single-cell cloning using automated, image-based cloning technology, ensuring high monoclonality rates. This workflow increases your chances of identifying top-performing clones early—saving time and reducing risk.
Our approach is ideal for both New Biological Entities (NBEs) and Biosimilars, ensuring a balance between high productivity, biosimilarity, and desired quality attributes.
By combining creative cell line technologies with expert-driven customization, CHOnamite® ensures superior performance, regulatory readiness, and seamless integration into biopharmaceutical manufacturing.
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Our team typically responds within 24 hours.
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Illustration designer: Tilo Schneider